Dr. Jonathan Grinstein MD

Dr. Grinstein is an Associate Professor of Medicine at The University of Chicago where he serves as the Director of Mechanical Circulatory Support and Director of Research. Dr. Grinstein graduated with an Honors in Physiology at McGill University before obtaining his medical degree at The University of Chicago. He completed his Internal Medicine training at Brigham and Women’s Hospital before returning to The University of Chicago for his Cardiovascular and Advanced Heart Failure Training. He is passionate about furthering medicine through research. Dr. Grinstein has evaluated and perfected echocardiographic and computed tomography techniques that noninvasively monitor the pressure and volume inside the heart for patients with an implanted LVAD. This technique allows cardiologists to analyze how well a patient is responding to the device and make necessary adjustments in real time. Additionally, Dr. Grinstein is conducting research to develop a “smart” LVAD that can intuitively adjust its speed based on the physiological needs of the patient. He is also using computational fluid dynamics to study and predict blood flow patterns through the LVAD to maximize device performance. Currently, he is developing machine learning models to predict heart failure events based on a patient’s unique hemodynamic and energetic profile.

Dr. Grinstein’s research has been published in several high-impact, peer-reviewed journals, including the Journal of the American College of Cardiology, the Journal of Cardiac Failure, American Society for Artificial Internal Organs Journal, Journal of Heart and Lung Transplantation, JACC: Heart Failure, Circulation: Heart Failure and JACC: Cardiovascular Imaging.